Abstract
Genome-Wide Association Studies (GWAS) offer an exciting and promising new research avenue for finding genes for complex diseases. Traditional case-control and cohort studies offer many advantages for such designs. Family-based association designs have long been attractive for their robustness properties, but robustness can mean a loss of power. In this paper we discuss some of the special features of family designs and their relevance in the era of GWAS.
Citation
Nan M. Laird. Christoph Lange. "The Role of Family-Based Designs in Genome-Wide Association Studies." Statist. Sci. 24 (4) 388 - 397, November 2009. https://doi.org/10.1214/08-STS280
Information