Abstract
Let the design of an experiment be represented by an $s$-dimensional vector $\mathbf{w}$ of weights with nonnegative components. Let the quality of $\mathbf{w}$ for the estimation of the parameters of the statistical model be measured by the criterion of $D$-optimality, defined as the $m$th root of the determinant of the information matrix $M(\mathbf{w} )=\sum_{i=1}^{s}w_{i}A_{i}A_{i}^{T}$, where $A_{i},i=1,\ldots,s$ are known matrices with $m$ rows.
In this paper, we show that the criterion of $D$-optimality is second-order cone representable. As a result, the method of second-order cone programming can be used to compute an approximate $D$-optimal design with any system of linear constraints on the vector of weights. More importantly, the proposed characterization allows us to compute an exact $D$-optimal design, which is possible thanks to high-quality branch-and-cut solvers specialized to solve mixed integer second-order cone programming problems. Our results extend to the case of the criterion of $D_{K}$-optimality, which measures the quality of $\mathbf{w}$ for the estimation of a linear parameter subsystem defined by a full-rank coefficient matrix $K$.
We prove that some other widely used criteria are also second-order cone representable, for instance, the criteria of $A$-, $A_{K}$-, $G$- and $I$-optimality.
We present several numerical examples demonstrating the efficiency and general applicability of the proposed method. We show that in many cases the mixed integer second-order cone programming approach allows us to find a provably optimal exact design, while the standard heuristics systematically miss the optimum.
Citation
Guillaume Sagnol. Radoslav Harman. "Computing exact $D$-optimal designs by mixed integer second-order cone programming." Ann. Statist. 43 (5) 2198 - 2224, October 2015. https://doi.org/10.1214/15-AOS1339
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