Open Access
June 2016 A Bayesian approach to the semiparametric estimation of a minimum inhibitory concentration distribution
Stijn Jaspers, Philippe Lambert, Marc Aerts
Ann. Appl. Stat. 10(2): 906-924 (June 2016). DOI: 10.1214/16-AOAS918


Bacteria that have developed a reduced susceptibility against antimicrobials pose a major threat to public health. Hence, monitoring their distribution in the general population is of major importance. This monitoring is performed based on minimum inhibitory concentration (MIC) values, which are collected through dilution experiments. We present a semiparametric mixture model to estimate the MIC density on the full continuous scale. The wild-type first component is assumed to be of a parametric form, while the nonwild-type second component is modelled nonparametrically using Bayesian P-splines combined with the composite link model. A Metropolis within Gibbs strategy was used to draw a sample from the joint posterior. The newly developed method was applied to a specific bacterium–antibiotic combination, that is, Escherichia coli tested against ampicillin. After obtaining an estimate for the entire density, model-based classification can be performed to check whether or not an isolate belongs to the wild-type subpopulation. The performance of the new method, compared to two existing competitors, is assessed through a small simulation study.


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Stijn Jaspers. Philippe Lambert. Marc Aerts. "A Bayesian approach to the semiparametric estimation of a minimum inhibitory concentration distribution." Ann. Appl. Stat. 10 (2) 906 - 924, June 2016.


Received: 1 November 2014; Revised: 1 June 2015; Published: June 2016
First available in Project Euclid: 22 July 2016

zbMATH: 06625674
MathSciNet: MR3528365
Digital Object Identifier: 10.1214/16-AOAS918

Keywords: Antimicrobial resistance , Bayesian , composite link model , interval-censored , semiparametric

Rights: Copyright © 2016 Institute of Mathematical Statistics

Vol.10 • No. 2 • June 2016
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