May 2023 Comment: Group Sequential Designs with Response-Adaptive Randomisation
Christopher Jennison
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Statist. Sci. 38(2): 219-223 (May 2023). DOI: 10.1214/23-STS865D

Abstract

Group sequential Phase III trial designs enable early stopping for positive or negative study outcomes. Response-adaptive randomisation can be included in such designs with the sampling ratio in each group of subjects determined by the current treatment effect estimate. We demonstrate the potential of adaptive randomisation to reduce the number of patients receiving the inferior treatment, even when there is a delay in observing each patient’s response. We also observe that using a fixed but unequal sampling ratio may offer a simpler way to achieve the same objectives.

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Christopher Jennison. "Comment: Group Sequential Designs with Response-Adaptive Randomisation." Statist. Sci. 38 (2) 219 - 223, May 2023. https://doi.org/10.1214/23-STS865D

Information

Published: May 2023
First available in Project Euclid: 4 June 2023

MathSciNet: MR4597332
zbMATH: 07708426
Digital Object Identifier: 10.1214/23-STS865D

Keywords: group sequential test , inferior treatment number , Response-adaptive randomisation

Rights: Copyright © 2023 Institute of Mathematical Statistics

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Vol.38 • No. 2 • May 2023
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