Open Access
February 2014 Selecting a Biased-Coin Design
Anthony C. Atkinson
Statist. Sci. 29(1): 144-163 (February 2014). DOI: 10.1214/13-STS449


Biased-coin designs are used in clinical trials to allocate treatments with some randomness while maintaining approximately equal allocation. More recent rules are compared with Efron’s [Biometrika 58 (1971) 403–417] biased-coin rule and extended to allow balance over covariates. The main properties are loss of information, due to imbalance, and selection bias. Theoretical results, mostly large sample, are assembled and assessed by small-sample simulations. The properties of the rules fall into three clear categories. A Bayesian rule is shown to have appealing properties; at the cost of slight imbalance, bias is virtually eliminated for large samples.


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Anthony C. Atkinson. "Selecting a Biased-Coin Design." Statist. Sci. 29 (1) 144 - 163, February 2014.


Published: February 2014
First available in Project Euclid: 9 May 2014

zbMATH: 1332.62264
MathSciNet: MR3201860
Digital Object Identifier: 10.1214/13-STS449

Keywords: clinical trial , covariate balancing , loss of information , optimum experimental design , random allocation , selection bias

Rights: Copyright © 2014 Institute of Mathematical Statistics

Vol.29 • No. 1 • February 2014
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