Open Access
December 1997 An unbiased test for the bioequivalence problem
Lawrence D. Brown, J. T. Gene Hwang, Axel Munk
Ann. Statist. 25(6): 2345-2367 (December 1997). DOI: 10.1214/aos/1030741076

Abstract

It is shown that the standard two one-sided tests procedure for bioequivalence is a biased test. Better tests exist. In this paper, an unbiased $\alpha$-level test and other tests which are uniformly more powerful than the two one-sided tests procedure are constructed. Its power can be noticeably larger than that of the $\alpha$-level two one-sided tests procedure.

Citation

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Lawrence D. Brown. J. T. Gene Hwang. Axel Munk. "An unbiased test for the bioequivalence problem." Ann. Statist. 25 (6) 2345 - 2367, December 1997. https://doi.org/10.1214/aos/1030741076

Information

Published: December 1997
First available in Project Euclid: 30 August 2002

zbMATH: 0905.62107
MathSciNet: MR1604461
Digital Object Identifier: 10.1214/aos/1030741076

Subjects:
Primary: 62F04
Secondary: 62P10

Keywords: pharmocokinetic parameters , Two one-sided tests procedure , uniformly more powerful

Rights: Copyright © 1997 Institute of Mathematical Statistics

Vol.25 • No. 6 • December 1997
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