Open Access
September 2012 Network inference and biological dynamics
Chris. J. Oates, Sach Mukherjee
Ann. Appl. Stat. 6(3): 1209-1235 (September 2012). DOI: 10.1214/11-AOAS532


Network inference approaches are now widely used in biological applications to probe regulatory relationships between molecular components such as genes or proteins. Many methods have been proposed for this setting, but the connections and differences between their statistical formulations have received less attention. In this paper, we show how a broad class of statistical network inference methods, including a number of existing approaches, can be described in terms of variable selection for the linear model. This reveals some subtle but important differences between the methods, including the treatment of time intervals in discretely observed data. In developing a general formulation, we also explore the relationship between single-cell stochastic dynamics and network inference on averages over cells. This clarifies the link between biochemical networks as they operate at the cellular level and network inference as carried out on data that are averages over populations of cells. We present empirical results, comparing thirty-two network inference methods that are instances of the general formulation we describe, using two published dynamical models. Our investigation sheds light on the applicability and limitations of network inference and provides guidance for practitioners and suggestions for experimental design.


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Chris. J. Oates. Sach Mukherjee. "Network inference and biological dynamics." Ann. Appl. Stat. 6 (3) 1209 - 1235, September 2012.


Published: September 2012
First available in Project Euclid: 31 August 2012

zbMATH: 1257.62108
MathSciNet: MR3012527
Digital Object Identifier: 10.1214/11-AOAS532

Keywords: biological dynamics , Network inference , Variable selection

Rights: Copyright © 2012 Institute of Mathematical Statistics

Vol.6 • No. 3 • September 2012
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