Journal of Applied Mathematics

A Time Scales Approach to Coinfection by Opportunistic Diseases

Marcos Marvá, Ezio Venturino, and Rafael Bravo de la Parra

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Abstract

Traditional biomedical approaches treat diseases in isolation, but the importance of synergistic disease interactions is now recognized. As a first step we present and analyze a simple coinfection model for two diseases simultaneously affecting a population. The host population is affected by the primary disease, a long-term infection whose dynamics is described by a SIS model with demography, which facilitates individuals acquiring a second disease, secondary (or opportunistic) disease. The secondary disease is instead a short-term infection affecting only the primary infected individuals. Its dynamics is also represented by a SIS model with no demography. To distinguish between short- and long-term infection the complete model is written as a two-time-scale system. The primary disease acts at the slow time scale while the secondary disease does at the fast one, allowing a dimension reduction of the system and making its analysis tractable. We show that an opportunistic disease outbreak might change drastically the outcome of the primary epidemic process, although it does among the outcomes allowed by the primary disease. We have found situations in which either acting on the opportunistic disease transmission or recovery rates or controlling the susceptible and infected population size allows eradicating/promoting disease endemicity.

Article information

Source
J. Appl. Math., Volume 2015 (2015), Article ID 275485, 10 pages.

Dates
First available in Project Euclid: 11 June 2015

Permanent link to this document
https://projecteuclid.org/euclid.jam/1434042411

Digital Object Identifier
doi:10.1155/2015/275485

Mathematical Reviews number (MathSciNet)
MR3342054

Citation

Marvá, Marcos; Venturino, Ezio; Bravo de la Parra, Rafael. A Time Scales Approach to Coinfection by Opportunistic Diseases. J. Appl. Math. 2015 (2015), Article ID 275485, 10 pages. doi:10.1155/2015/275485. https://projecteuclid.org/euclid.jam/1434042411


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