Potential violent criminals will often need to go through a sequence of preparatory steps before they can execute their plans. During this escalation process police have the opportunity to evaluate the threat posed by such people through what they know, observe and learn from intelligence reports about their activities. In this paper we customise a three-level Bayesian hierarchical model to describe this process. This is able to propagate both routine and unexpected evidence in real time. We discuss how to set up such a model so that it calibrates to domain expert judgments. The model illustrations include a hypothetical example based on a potential vehicle based terrorist attack.

In the context of robust Bayesian analysis for multiparameter distributions, we introduce a new class of priors based on stochastic orders, multivariate total positivity of order 2 ($MT{P}_2$) and weighted distributions. We provide the new definition, its interpretation and the main properties and we also study the relationship with other classical classes of prior beliefs. We also consider the Hellinger metric and the Kullback-Leibler divergence to measure the uncertainty induced by such a class, as well as its effect on the posterior distribution. Finally, we conclude the paper with a real example about train door reliability.

Exposure to air pollution in the form of fine particulate matter (${\mathrm{PM}}_{2.5}$) is known to cause diseases and cancers. Consequently, the public are increasingly seeking health warnings associated with levels of ${\mathrm{PM}}_{2.5}$ using mobile phone applications and websites. Often, these existing platforms provide one-size-fits-all guidance, not incorporating user specific personal preferences.

This study demonstrates an innovative approach using Bayesian methods to support personalised decision making for air quality. We present a novel hierarchical spatio-temporal model for city air quality that includes buildings as barriers and captures covariate information. Detailed high resolution ${\mathrm{PM}}_{2.5}$ data from a single mobile air quality sensor is used to train the model, which is fit using R-INLA to facilitate computation at operational timescales. A method for eliciting multi-attribute utility for individual journeys within a city is then given, providing the user with Bayes-optimal journey decision support. As a proof-of-concept, the methodology is demonstrated using a set of journeys and air quality data collected in Brisbane city centre, Australia.

Uniformly most powerful Bayesian tests (UMPBT’s) are an objective class of Bayesian hypothesis tests that can be considered the Bayesian counterpart of classical uniformly most powerful tests. Because the rejection regions of UMPBT’s can be matched to the rejection regions of classical uniformly most powerful tests (UMPTs), UMPBT’s provide a mechanism for calibrating Bayesian evidence thresholds, Bayes factors, classical significance levels and p-values. The purpose of this article is to expand the application of UMPBT’s outside the class of exponential family models. Specifically, we introduce sufficient conditions for the existence of UMPBT’s and propose a unified approach for their derivation. An important application of our methodology is the extension of UMPBT’s to testing whether the non-centrality parameter of a chi-squared distribution is zero. The resulting tests have broad applicability, providing default alternative hypotheses to compute Bayes factors in, for example, Pearson’s chi-squared test for goodness-of-fit, tests of independence in contingency tables, and likelihood ratio, score and Wald tests.

The problem of testing mutually exclusive hypotheses with dependent test statistics is considered. Bayesian and frequentist approaches to multiplicity control are studied and compared to help gain understanding as to the effect of test statistic dependence on each approach. The Bayesian approach is shown to have excellent frequentist properties and is argued to be the most effective way of obtaining frequentist multiplicity control, without sacrificing power, when there is considerable test statistic dependence.

In this paper, objective Bayesian analysis for the Student-t linear regression model with unknown degrees of freedom is studied. The reference priors under all the possible group orderings for the parameters in the model are derived. The posterior propriety under each reference prior is validated by considering a larger class of priors. Simulation studies are carried out to investigate the frequentist properties of Bayesian estimators based on the reference priors. Finally, the Bayesian approach is applied to two real data sets.

We consider Bayesian inference when only a limited number of noisy log-likelihood evaluations can be obtained. This occurs for example when complex simulator-based statistical models are fitted to data, and synthetic likelihood (SL) method is used to form the noisy log-likelihood estimates using computationally costly forward simulations. We frame the inference task as a sequential Bayesian experimental design problem, where the log-likelihood function is modelled with a hierarchical Gaussian process (GP) surrogate model, which is used to efficiently select additional log-likelihood evaluation locations. Motivated by recent progress in the related problem of batch Bayesian optimisation, we develop various batch-sequential design strategies which allow to run some of the potentially costly simulations in parallel. We analyse the properties of the resulting method theoretically and empirically. Experiments with several toy problems and simulation models suggest that our method is robust, highly parallelisable, and sample-efficient.

This paper proposes a Bayesian adaptive basket trial design to optimize the dose–schedule regimes of an experimental agent within disease subtypes, called “baskets”, for phase I–II clinical trials based on late-onset efficacy and toxicity. To characterize the association among the baskets and regimes, a Bayesian hierarchical model is assumed that includes a heterogeneity parameter, adaptively updated during the trial, that quantifies information shared across baskets. To account for late-onset outcomes when doing sequential decision making, unobserved outcomes are treated as missing values and imputed by exploiting early biomarker and low-grade toxicity information. Elicited joint utilities of efficacy and toxicity are used for decision making. Patients are randomized adaptively to regimes while accounting for baskets, with randomization probabilities proportional to the posterior probability of achieving maximum utility. Simulations are presented to assess the design’s robustness and ability to identify optimal dose–schedule regimes within disease subtypes, and to compare it to a simplified design that treats the subtypes independently.

Any Bayesian analysis involves combining information represented through different model components, and when different sources of information are in conflict it is important to detect this. Here we consider checking for prior-data conflict in Bayesian models by expanding the prior used for the analysis into a larger family of priors, and considering a marginal likelihood score statistic for the expansion parameter. Consideration of different expansions can be informative about the nature of any conflict, and an appropriate choice of expansion can provide more sensitive checks for conflicts of certain types. Extensions to hierarchically specified priors and connections with other approaches to prior-data conflict checking are considered, and implementation in complex situations is illustrated with two applications. The first concerns testing for the appropriateness of a LASSO penalty in shrinkage estimation of coefficients in linear regression. Our method is compared with a recent suggestion in the literature designed to be powerful against alternatives in the exponential power family, and we use this family as the prior expansion for constructing our check. A second application concerns a problem in quantum state estimation, where a multinomial model is considered with physical constraints on the model parameters. In this example, the usefulness of different prior expansions is demonstrated for obtaining checks which are sensitive to different aspects of the prior.

We address the problem of dynamic variable selection in time series regression with unknown residual variances, where the set of active predictors is allowed to evolve over time. To capture time-varying variable selection uncertainty, we introduce new dynamic shrinkage priors for the time series of regression coefficients. These priors are characterized by two main ingredients: smooth parameter evolutions and intermittent zeroes for modeling predictive breaks. More formally, our proposed Dynamic Spike-and-Slab (DSS) priors are constructed as mixtures of two processes: a spike process for the irrelevant coefficients and a slab autoregressive process for the active coefficients. The mixing weights are themselves time-varying and depend on lagged values of the series. Our $DSS$ priors are probabilistically coherent in the sense that their stationary distribution is fully known and characterized by spike-and-slab marginals. For posterior sampling over dynamic regression coefficients, model selection indicators as well as unknown dynamic residual variances, we propose a Dynamic SSVS algorithm based on forward-filtering and backward-sampling. To scale our method to large data sets, we develop a Dynamic EMVS algorithm for MAP smoothing. We demonstrate, through simulation and a topical macroeconomic dataset, that $DSS$ priors are very effective at separating active and noisy coefficients. Our fast implementation significantly extends the reach of spike-and-slab methods to big time series data.

We consider the variable selection problem when the response is subject to censoring. A main particularity of this context is that information content of sampled units varies depending on the censoring times. Our approach is based on model selection where all $2^k$ possible models are entertained and we adopt an objective Bayesian perspective where the choice of prior distributions is a delicate issue given the well-known sensitivity of Bayes factors to these prior inputs. We show that borrowing priors from the ‘uncensored’ literature may lead to unsatisfactory results as this default procedure implicitly assumes a uniform contribution of all units independently on their censoring times. In this paper, we develop specific methodology based on a generalization of the g-priors, explicitly addressing the particularities of survival problems arguing that it behaves comparatively better than standard approaches on the basis of arguments specific to variable selection problems (like e.g. predictive matching) in the particular case of the accelerated failure time model with lognormal errors. We apply the methodology to a recent large epidemiological study about breast cancer survival rates in Castellón, a province of Spain.

There is a very rich literature proposing Bayesian approaches for clustering starting with a prior probability distribution on partitions. Most approaches assume exchangeability, leading to simple representations in terms of Exchangeable Partition Probability Functions (EPPF). Gibbs-type priors encompass a broad class of such cases, including Dirichlet and Pitman-Yor processes. Even though there have been some proposals to relax the exchangeability assumption, allowing covariate-dependence and partial exchangeability, limited consideration has been given on how to include concrete prior knowledge on the partition. For example, we are motivated by an epidemiological application, in which we wish to cluster birth defects into groups and we have prior knowledge of an initial clustering provided by experts. As a general approach for including such prior knowledge, we propose a Centered Partition (CP) process that modifies the EPPF to favor partitions close to an initial one. Some properties of the CP prior are described, a general algorithm for posterior computation is developed, and we illustrate the methodology through simulation examples and an application to the motivating epidemiology study of birth defects.