Bayesian Analysis

Spatial mixture modelling for unobserved point processes: examples in immunofluorescence histology

Chunlin Ji, Thomas B. Kepler, Daniel Merl, and Mike West

Full-text: Open access

Abstract

We discuss Bayesian modelling and computational methods in analysis of indirectly observed spatial point processes. The context involves noisy measurements on an underlying point process that provide indirect and noisy data on locations of point outcomes. We are interested in problems in which the spatial intensity function may be highly heterogenous, and so is modelled via flexible nonparametric Bayesian mixture models. Analysis aims to estimate the underlying intensity function and the abundance of realized but unobserved points. Our motivating applications involve immunological studies of multiple fluorescent intensity images in sections of lymphatic tissue where the point processes represent geographical configurations of cells. We are interested in estimating intensity functions and cell abundance for each of a series of such data sets to facilitate comparisons of outcomes at different times and with respect to differing experimental conditions. The analysis is heavily computational, utilizing recently introduced MCMC approaches for spatial point process mixtures and extending them to the broader new context here of unobserved outcomes. Further, our example applications are problems in which the individual objects of interest are not simply points, but rather small groups of pixels; this implies a need to work at an aggregate pixel region level and we develop the resulting novel methodology for this. Two examples with with immunofluorescence histology data demonstrate the models and computational methodology.

Article information

Source
Bayesian Anal., Volume 4, Number 2 (2009), 297-315.

Dates
First available in Project Euclid: 22 June 2012

Permanent link to this document
https://projecteuclid.org/euclid.ba/1340370279

Digital Object Identifier
doi: 10.1214/09-BA411

Mathematical Reviews number (MathSciNet)
MR2507365

Zentralblatt MATH identifier
1330.62355

Keywords
Bayesian computation blocked Gibbs sampler Dirichlet process mixture model inhomogeneous Poisson process unobserved point process

Citation

Ji, Chunlin; Merl, Daniel; Kepler, Thomas B.; West, Mike. Spatial mixture modelling for unobserved point processes: examples in immunofluorescence histology. Bayesian Anal. 4 (2009), no. 2, 297--315. doi:10.1214/09-BA411. https://projecteuclid.org/euclid.ba/1340370279


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