The Annals of Statistics

High-dimensional $A$-learning for optimal dynamic treatment regimes

Chengchun Shi, Ailin Fan, Rui Song, and Wenbin Lu

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Abstract

Precision medicine is a medical paradigm that focuses on finding the most effective treatment decision based on individual patient information. For many complex diseases, such as cancer, treatment decisions need to be tailored over time according to patients’ responses to previous treatments. Such an adaptive strategy is referred as a dynamic treatment regime. A major challenge in deriving an optimal dynamic treatment regime arises when an extraordinary large number of prognostic factors, such as patient’s genetic information, demographic characteristics, medical history and clinical measurements over time are available, but not all of them are necessary for making treatment decision. This makes variable selection an emerging need in precision medicine.

In this paper, we propose a penalized multi-stage $A$-learning for deriving the optimal dynamic treatment regime when the number of covariates is of the nonpolynomial (NP) order of the sample size. To preserve the double robustness property of the $A$-learning method, we adopt the Dantzig selector, which directly penalizes the A-leaning estimating equations. Oracle inequalities of the proposed estimators for the parameters in the optimal dynamic treatment regime and error bounds on the difference between the value functions of the estimated optimal dynamic treatment regime and the true optimal dynamic treatment regime are established. Empirical performance of the proposed approach is evaluated by simulations and illustrated with an application to data from the STAR∗D study.

Article information

Source
Ann. Statist., Volume 46, Number 3 (2018), 925-957.

Dates
Received: January 2016
Revised: January 2017
First available in Project Euclid: 3 May 2018

Permanent link to this document
https://projecteuclid.org/euclid.aos/1525313071

Digital Object Identifier
doi:10.1214/17-AOS1570

Mathematical Reviews number (MathSciNet)
MR3797992

Zentralblatt MATH identifier
1398.62029

Subjects
Primary: 62C99: None of the above, but in this section
Secondary: 62J07: Ridge regression; shrinkage estimators

Keywords
$A$-learning Dantzig selector NP-dimensionality model misspecification optimal dynamic treatment regime oracle inequality

Citation

Shi, Chengchun; Fan, Ailin; Song, Rui; Lu, Wenbin. High-dimensional $A$-learning for optimal dynamic treatment regimes. Ann. Statist. 46 (2018), no. 3, 925--957. doi:10.1214/17-AOS1570. https://projecteuclid.org/euclid.aos/1525313071


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Supplemental materials

  • Supplement to “High-dimensional $\boldsymbol{A}$-learning for optimal dynamic treatment regimes”. Supplementary material includes some proofs.